🚨 Global Cancer Drug Scandal: India Under the Microscope
Explained
for UPSC Aspirants by Suryavanshi IAS
"When lives hang by a thread, there is no
room for negligence."
A major
international investigation Bureau of Investigative Journalism,
has sent shockwaves through the global medical and pharmaceutical world: cancer drugs manufactured in India and shipped to
over 100 countries have failed quality tests.
These drugs, vital for millions of patients battling various forms of cancer, are now under scrutiny. Here's what every UPSC aspirant must know — not just to crack the exam, but to understand the gravity of public health ethics, regulation, and policy lapses.
🔬
What Is Cancer?
Cancer is caused by uncontrolled cell division, typically due to mutations in genes. These mutations
disrupt normal processes like cell death or repair, leading to tumour formation.
🧪 To combat this, chemotherapy drugs are used to kill or inhibit the replication of cancer cells — but they often come with serious side effects because they may also affect healthy cells, especially those that divide rapidly (e.g., bone marrow, hair follicles).
🧾
Six Cancer Drugs Under Scrutiny
Below are the six chemotherapy drugs identified in the report, their scientific roles, and why their failure is catastrophic:
1. Cisplatin
Platinum-based
chemotherapy drug discovered in the 1960s.
·
How it
works: Binds to DNA and prevents cancer cells from replicating.
·
Used for:
Testicular, ovarian, bladder, and some lung cancers.
·
Risks:
o Kidney
damage
o Hearing
loss
o Bone
marrow suppression → low white blood cells → infections
📌 UPSC Angle: Platinum-based therapy; DNA-targeting mechanisms in chemotherapy; high toxicity vs. effectiveness debate.
2. Oxaliplatin
Similar to cisplatin, but more specific to
gastrointestinal cancers.
·
How it
works: Causes DNA damage in cancer cells.
·
Used for:
Advanced colorectal cancer, especially post-surgery.
·
Risks:
o Neuropathy
(nerve damage)
o Immunosuppression
📌 UPSC Angle: Mention in GS3 for public health examples; cancer post-surgical therapy strategies.
3. Cyclophosphamide
A widely
used alkylating agent in cancer therapy.
·
How it
works: Cross-links DNA strands, stopping cell division.
·
Used for:
Breast cancer, leukaemia, lymphoma, sarcoma.
·
Risks:
o Hemorrhagic
cystitis (painful urination)
o Immune
suppression
📌 UPSC Angle: Chemotherapy protocols; health infrastructure issues in oncology.
4. Doxorubicin
(The “Red Devil”)
An antibiotic-turned-anticancer drug derived
from Streptomyces.
·
How it
works: Inserts itself into DNA and disrupts replication.
·
Used for:
Breast cancer, sarcomas, lymphomas, leukaemia.
·
Risks:
o Heart toxicity (cardiomyopathy)
o Severe
nausea, hair loss, infection risk
📌 UPSC Angle: Biotechnology and pharmacology ethics; microbial drugs in oncology.
5. Methotrexate
An anti-metabolite
and immunosuppressant.
·
How it
works: Inhibits folate metabolism, which is critical for DNA
synthesis.
·
Used for:
Leukaemia, lymphoma, choriocarcinoma, rheumatoid arthritis.
·
Risks:
o Liver
toxicity
o Bone
marrow suppression
📌 UPSC Angle: Example in GS2 (health policies) and GS3 (science-tech); also used in autoimmune disease therapy.
6. Leucovorin
(Folinic Acid)
A supportive
agent, not a chemotherapy drug per se.
·
How it
works: Protects normal cells from methotrexate toxicity by providing
an alternate source of folate.
·
Used for:
Rescue therapy with methotrexate; sometimes enhances 5-FU action.
·
Risks:
Minimal, as it’s a protective vitamin-based compound.
📌 UPSC Angle: Role of companion drugs in chemotherapy; drug synergy and cellular rescue protocols.
🌐
The Scandal: Global Health at Risk
·
More than
100 countries have received these drugs from Indian exporters.
·
Investigations show batch failures, impurities,
and mislabeling.
·
Exported
drugs had higher failure rates than domestic ones – raising concerns
of double standards.
· Patients in developing nations rely heavily on affordable generics — but this quality lapse threatens global trust.
⚖️ Ethical
and Regulatory Implications
🔍 Key Concerns:
·
Lax testing of exported drug batches
·
Inadequate global oversight
·
Ethical concerns: Do poorer nations deserve
lower quality drugs?
💡 Ethics Paper Point: Discuss the conflict between affordability and quality in essential medicines.
📚
UPSC Relevance Breakdown
🔹 Prelims
·
Disease & drug basics
·
Platinum-based chemo drugs
·
Indian pharma exports
🔹 GS Paper 2 – Governance & Health
·
Regulatory bodies (e.g., CDSCO, WHO)
·
International health diplomacy
·
Right to health and ethical drug production
🔹 GS Paper 3 – Science, Tech & Environment
·
Biochemistry of cancer
·
Drug development pipeline
·
Indian pharmaceutical industry
🔹 Essay / Ethics
·
Justice in healthcare
·
Regulation vs. profit
· Role of the state in public health safety
🧭
Final Thoughts by Suryavanshi IAS
India is known as the “pharmacy of the world”, but incidents like this
question the integrity of our exports,
oversight mechanisms, and ethical standards.
UPSC Aspirants must not only understand the science behind these drugs, but also be able to critically analyze the governance gaps, ethical concerns, and global impact of such failures.
🎯
Want to Master Such Topics with Precision?
🌟 Join the Suryavanshi IAS Foundation Programme for UPSC 2025:
·
🔬 In-depth Science & Tech + Current Affairs Integration
·
🧠 Ethics Case Studies from real-life
investigations
·
📊 Daily MCQs & Mains Practice linked
with current topics
·
📘 Smart Notes on Health, Environment,
and Pharma Policies
💻 Online
& Offline Classes Available
📍 Visit: suryavanshiias.blogspot.com
📞 Call: 06306446114
for a free demo session
Stay curious.
Stay critical. Be the future IAS officer who not only cracks the paper, but
serves the nation.
– Team Suryavanshi IAS
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